Assistant Professor, Germ Cell Biology
BS, China Agricultural University
MS, Texas A&M University
PhD, Washington University School of Medicine
Postdoc, University of Toronto
My laboratory studies the molecular mechanisms underlying mammalian spermatogenesis and infertility using molecular, cellular, biochemical, mouse genetics and genomics approaches. The lab is broadly interested in genes and pathways influencing germ/stem cell self-renewal, differentiation and fertility with a current focus on the function of Tudor domain proteins and other Piwi-piRNA pathway associated factors in gene silencing, genome stability, epigenetics, stem cell biology and cancer.
Chen C*, Nott TJ, Jin J, Pawson T*. Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):629-42. *Corresponding author.
Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, Mackenzie F, Pan P, Li SS, Wang H, Min J. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19266-7.
Liu K*, Chen C*, Guo Y*, Lam R, Bian C, Xu C, Zhao DY, Jin J, MacKenzie F, Pawson T, Min J. Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18398-403. *Equal contribution.
Chen C, Jin J, James DA, Adams-Cioaba MA, Park JG, Guo Y, Tenaglia E, Xu C, Gish G, Min J, Pawson T. Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41.
Jin J, Xie X*, Chen C*, Park JG, Stark C, James DA, Olhovsky M, Linding R, Mao Y, Pawson T. Eukaryotic protein domains as functional units of cellular evolution. Science Signaling. 2009 Nov 24;2(98):ra76. *Equal contribution.
Chen C, Ouyang W, Grigura V, Zhou Q, Lim H, Zhao GQ, Carnes K, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann M, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature. 2005 August 18; 436:1030-34.
The Chen Lab is inviting applications for a postdoctoral fellow position starting in 2015/2016. Interested applicants please send your CV and names and contact information of three references to Dr. Chen Chen.