Jim Ireland

Professor, Reproductive Physiology

Jim Ireland
1230I Anthony Hall

Phone: (517) 432-1384

Affiliations

Joint appointment in Physiology

Advantages of Domestic Species as Dual-Use Models that Benefit Agricultural and Biomedial Research

Reproductive Developmental Sciences Program

Education

  • BS, Austin Peay State University
  • PhD, University of Tennessee
  • Postdoctoral Fellow, University of Michigan
  • NIH Senior Fellow (Sabbatical), Yale School of Medicine

Responsibility

95% Research, 5% Teaching

Research

I focus on the following four areas of reproduction in cattle:

  1. determination of whether anti-Müllerian hormone (ovarian growth factor produced by healthy growing ovarian follicles) is a reliable biomarker to predict future fertility, health and herd longevity of dairy cows;
  2. development of new, more efficient superovulation techniques to improve embryo transfer in cattle that may also benefit assisted reproductive technologies (ART) in women,
  3. determination of the mechanisms whereby excessive hormonal treatments during superovulation impair embryo survival, and
  4. determination of the role of excessive maternal androgen production in cows induced by mild nutrition restriction during the first trimester of pregnancy on health and fertility of their female progeny. 

My research is currently funded by AgBioResearch and grants from USDA-NIFA-AFRI and the “dual purpose research program” sponsored by NIH-USDA-NIFA-AFRI. 

Teaching

Coordinator for ANS 409: Selected Topics: Problems, Controversies and Advancements in Reproduction.

Selected Publications

Ireland JJ, Smith GW, Scheetz D, Jimenez-Krassel J, Folger JK, Ireland JLH, Mossa F,  Lonergan P, Evans ACO. 2010. Does Size Matter in Females?  An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of AMH as a diagnostic marker for fertility, and causes of variation in the ovarian reserve in cattle. Reprod Fert Dev 23:1-14.

Mossa F, Carter F, Walsh SW, Kenny DA, Smith GW, Ireland JLH, Hildebrandt TB, Lonergan P, Ireland JJ, Evans ACO. 2013. Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring. Biol Reprod 88:1-9.

Walsh SW, Mossa F, Butler ST, Berry DP, Scheetz D, Jimenez-Krassel F, Tempelman RJ, Carter F, Lonergan P, Evans ACO, Ireland JJ. 2014. Heritability and impact of environmental effects during pregnancy on antral follicle count in cattle. J Dairy Sci. 97:4503-4511.

Jimenez-Krassel F, Scheetz D, Neuder LM, Ireland JLH, Pursley JR, Smith GW, Tempelman RJ, Ferris T, Roudebush WE, Mossa F, Lonergan P, Evans ACO, Ireland JJ. 2015. Concentration of anti-Müllerian in dairy heifers is positively associated with productive herd life. J Dairy Sci. 98:3036-3045.

Baker VL, Brown MB, Luke B, Smith GW, Ireland JJ. 2015. Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. Fertil Steril 104: 1145-1152.

Also see PubMed listing of publications.

chart of live birth rate versus total FSH dose

chart of number of healthy follicles per animal

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