Contact

Dept. of Animal Science
Anthony Hall
474 S. Shaw Lane
East Lansing, MI
48824-1225

Location

Phone: (517) 355-8383
Fax: (517) 353-1699
E-mail: .(JavaScript must be enabled to view this email address)

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Jason Knott

Jason Knott

Associate Professor

1230H Anthony Hall

(517) 432-5446

Associate Professor, Developmental Epigenetics & Reproductive Biology

Email:  .(JavaScript must be enabled to view this email address)

Web pages:
Community of Science Profile

Education
BS, University of Massachusetts, Amherst
PhD, University of Massachusetts, Amherst
Post-Doc, University of Pennsylvania
Post-Doc, EMD-Serono

Responsibility
40% teaching, 60% research

I teach half of Advanced Animal Genetics (ANS 404) and Principles of Animal Biotechnology (ANS 425) during alternating spring semesters.

Research conducted in my laboratory is aimed at understanding the genetic and epigenetic basis for cellular differentiation in the mammalian embryo. The model systems we are implementing include the mouse preimplantation embryo and embryonic stem (ES) cells. Presently, we are investigating the role of SWI/SNF chromatin remodeling proteins in ES cell pluripotency and lineage-specification. In other cellular contexts the SWI/SNF-Brg1 chromatin remodeler plays important roles in muscle, neuronal, lymphoid and myeloid differentiation through the activation and repression of gene expression. To better understand the role of Brg1 during early embryonic development we are utilizing a number of molecular techniques including transgenic RNA interference (RNAi), gene expression analysis and genome-wide promoter analysis (ChIP-chip). The results of our analysis so far have identified a subset of genes regulated by SWI/SNF-Brg1 that are critical for preimplantation embryo development and ES cell pluripotency. This work has implications in assisted reproductive technologies (ART) and cellular reprogramming for cell replacement therapies as well as broader implications in cancer.